CASP7 (caspase 7, apoptosis-related cysteine peptidase)

CASP - 9 ( caspase 9 , apoptosis - related cysteine peptidase )

Three mRNA isoforms have been identified in Homo sapiens. Caspase-9S, also classified as caspase-9b or caspase9beta, is a small variant of caspase-9 lacking exons 3-6, which contain the catalytic domain. Caspase-9S functions as an endogenous dominant-negative isoform of full-length caspase-9 by binding to the Apaf-1 protein thus hampering its binding and processing of the full-length procaspase...

CASP 8 ( Caspase 8 , Apoptosis - Related Cysteine Peptidase )

Review on CASP8, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

CASP 1 ( caspase 1 , apoptosis - related cysteine peptidase ( interleukin 1 , beta , convertase ) )

KLK 7 ( kallikrein - related peptidase 7 )

Five variant mRNA transcripts have been identi-fied. These include transcripts using different 5' untranslated regions (UTRs) including exon 1 deletions, and transcripts using different 3'UTR regions. Using rapid amplification of cDNA ends (RACE) different KLK7 5'UTR sequences were identified from RNA extracted from pancreas, skin and ovarian cells, suggesting the expression of tissue specific ...

Econazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways

Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...